2001 MAR 22 - (NewsRx.com & NewsRx.net) --
by Michael Greer, staff medical writer -- Researchers in Japan have found bacterial activators of the coagulatory blood factor IX, the first reported bacterial agents with this ability.
T. Imamura and colleagues at Kumamoto University examined two cysteine proteinases, known collectively as gingipains R, from the periodontitis-causing Porphyromonas gingivalis bacterium.
They found that both complex and single-chain gingipains R induced rapid factor IX activation, providing a possible explanation for how P. gingivalis can cause gum disease. By activating factor IX, gingipains R exposure can lead to thrombin …
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